Original publications
Latest Research
Selected research with implications for clinical practice. Click a headline to read the original journal article.
- Escitalopram and amitriptyline prolonged QTc, but trials detected no increase in early major cardiovascular events with antidepressants.
BMJ
- Atenolol was associated with fewer cardiovascular events than bisoprolol after MI without recorded heart failure.
NEJM Evidence
- Multicancer blood testing detected cancer in about 1 in 185 screened adults in PATHFINDER 2.
Nature Medicine
- Higher blood pressure, older age and tenecteplase dose were linked to intracranial bleeding after STEMI thrombolysis.
European Heart Journal
- The SAFE score showed the greatest clinical utility for predicting cirrhosis in steatotic liver disease.
JAMA Internal Medicine
- Protection from tuberculosis preventive treatment wanes sooner in high-burden settings.
The Lancet Respiratory Medicine
- RSV vaccination was associated with substantially fewer hospitalizations in older adults.
JAMA Network Open
- Higher maternal egg and peanut intake did not prevent infant egg or peanut allergy.
NEJM
- Carotid revascularization did not improve cognition beyond intensive medical treatment.
JAMA
- Whole grains modestly improved LDL cholesterol and other cardiometabolic risk factors.
European Heart Journal
- Lower intraoperative fluid use was not associated with more postoperative acute kidney injury.
JAMA Network Open
- Adding IVIG to prednisone improved early recovery in newly diagnosed inflammatory myopathy.
JAMA Neurology
- Nirsevimab was associated with substantially fewer infant RSV hospitalizations.
JAMA Network Open
- Adoption of azithromycin prophylaxis for unscheduled cesarean delivery was associated with fewer postpartum infections.
JAMA
- Febrile seizures were generally associated with minimal differences in later school performance.
JAMA Network Open
- Loberamisal improved stroke recovery in a Chinese phase 3 trial.
JAMA
- Oveporexton improved wakefulness and reduced cataplexy in narcolepsy type 1.
NEJM
- Starting with 30% oxygen rather than air did not reduce respiratory support in moderately preterm infants.
JAMA
- Tozorakimab reduced COPD exacerbations in two phase 3 trials.
NEJM
- Atezolizumab did not significantly improve event-free survival in early triple-negative breast cancer.
Nature Medicine
- Catheter-directed thrombolysis reduced early deterioration in intermediate-high-risk pulmonary embolism.
NEJM
- Omitting aspirin from initial low-dose prasugrel treatment in STEMI failed to demonstrate noninferior ischaemic protection.
NEJM
- Clopidogrel alone after 12 months of coronary stenting reduced bleeding but increased ischaemic events in high-risk patients.
NEJM
- A default prasugrel policy did not reduce ischaemic events versus ticagrelor after PCI for acute coronary syndrome.
NEJM
- Potent P2Y12 inhibitors with a DOAC raised bleeding concerns in AF with acute coronary syndrome.
Nature Medicine
- Atorvastatin reduced cardiovascular events in healthy adults aged ≥70, without improving disability-free survival.
NEJM
- DOAC therapy reduced net adverse clinical events in AF with one non-sex stroke-risk factor.
NEJM
- Eplontersen did not significantly reduce cardiovascular death or recurrent events in transthyretin amyloid cardiomyopathy.
NEJM
- Shorter, response-guided antibiotics increased treatment-free days in stable endocarditis but increased relapse.
NEJM
- Head elevation after thrombectomy did not significantly improve functional recovery compared with lying flat.
BMJ
- Preoperative intravenous iron reduced transfusions and modestly improved recovery after cardiac surgery in patients with anaemia.
BMJ
- Intravenous arginine did not shorten sickle-cell pain crises in children and young adults.
JAMA
- Daily zinc reduced infections in a small trial of young children with sickle-cell anaemia.
JAMA
- Platelets refrigerated for up to 21 days were noninferior to standard platelets for bleeding during cardiac surgery.
JAMA
- Five-fraction prostate radiotherapy improved bowel-related quality of life but was not superior for cancer control.
JAMA
- Intravenous anaesthesia did not improve days alive at home versus volatile anaesthesia after major noncardiac surgery.
JAMA
- A four-dose perioperative dapagliflozin regimen reduced acute kidney injury after elective cardiac surgery.
JAMA
- Weekly oral islatravir–lenacapavir was noninferior to daily bictegravir-based therapy for maintaining HIV suppression.
NEJM
- Oral amoxicillin step-down after clinical improvement was noninferior to continued IV treatment for severe childhood pneumonia without complicating factors.
The Lancet
- Perioperative enfortumab vedotin–pembrolizumab improved survival over cisplatin–gemcitabine in cisplatin-eligible muscle-invasive bladder cancer.
NEJM
- Thrombectomy did not improve recovery in medium or distal vessel stroke and caused more symptomatic haemorrhage.
JAMA
- Aspirin alone was noninferior to rivaroxaban followed by aspirin after hip or knee replacement.
NEJM
- Setmelanotide reduced BMI and hunger in acquired hypothalamic obesity, with more serious adverse events.
NEJM
- Rituximab was noninferior to ocrelizumab for MRI disease control in newly diagnosed relapsing multiple sclerosis.
NEJM
- Adding belzutifan to adjuvant pembrolizumab improved disease-free survival after kidney cancer surgery but increased severe toxicity.
NEJM